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Mismatch Repair Gene Test For Inherited Cancer Risk

Pennsylvania rates for HCPCS 81298

A laboratory test that reads a gene involved in repairing the errors cells make when they copy their DNA, looking for inherited changes that raise the risk of bowel, womb and several related cancers. It is ordered when a personal or family cancer history, or a finding in a tumor sample, points to an inherited cause.

Rates data updated October 2026.

How much does Mismatch Repair Gene Test For Inherited Cancer Risk cost?

$525

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $525 for this service. The price depends on where it is billed: about $501 from a physician practice, and about $646 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 10 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$501$398 to $550
FacilityA hospital or hospital-owned outpatient department$646$550 to $1,122

How much rates vary

Facilitymedian $646 · 10th to 90th $513 to $1,950Professionalmedian $501 · 10th to 90th $288 to $708
$200$1K$5K$20Kfacility $646professional $501

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$524.81
Median
$524.81
Typical High
$1,862.09
Aetna
Setting
Professional
Modifier
None
Typical Low
$512.86
Median
$524.81
Typical High
$549.54
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$251.19
Median
$257.04
Typical High
$275.42
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$102.33
Median
$104.71
Typical High
$109.65
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$5,011.87
Typical High
$79,432.82
Capital Blue Cross
Setting
Professional
Modifier
None
Typical Low
$446.68
Median
$501.19
Typical High
$691.83
Cigna
Setting
Facility
Modifier
None
Typical Low
$630.96
Median
$1,047.13
Typical High
$1,949.84
Cigna
Setting
Professional
Modifier
None
Typical Low
$302.00
Median
$602.56
Typical High
$977.24
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$380.19
Median
$831.76
Typical High
$831.76
Geisinger
Setting
Facility
Modifier
None
Typical Low
$645.65
Median
$645.65
Typical High
$645.65
Geisinger
Setting
Professional
Modifier
None
Typical Low
$645.65
Median
$977.24
Typical High
$1,621.81
Independence Blue Cross
Setting
Professional
Modifier
None
Typical Low
$645.65
Median
$645.65
Typical High
$645.65
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$524.81
Median
$524.81
Typical High
$2,187.76
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$524.81
Median
$524.81
Typical High
$549.54
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$257.04
Median
$257.04
Typical High
$275.42
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$104.71
Median
$104.71
Typical High
$109.65
UPMC Health Plan
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$524.81
Typical High
$1,584.89
UPMC Health Plan
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$316.23
Typical High
$645.65
United
Setting
Facility
Modifier
None
Typical Low
$575.44
Median
$645.65
Typical High
$776.25
United
Setting
Professional
Modifier
None
Typical Low
$269.15
Median
$323.59
Typical High
$741.31
1 more rate with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Highmark BCBS
Setting
Facility
Modifier
90 · Outside lab
Typical Low
$147.91
Median
$147.91
Typical High
$147.91

Where Pennsylvania sits

The same service costs 5.0 times more in Alaska than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 28th of 51

$525

AK $1,445NC $288

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.