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MTHFR Gene Variant Test

South Dakota rates for HCPCS 81291

A blood test that checks for specific common changes in the MTHFR gene, which makes an enzyme the body uses to process folate, a B vitamin. Carrying these changes can alter how efficiently that step works. The test looks only for those known common changes rather than reading the whole gene.

Rates data updated October 2026.

How much does MTHFR Gene Variant Test cost?

$74.13

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $74.13 for this service. The price depends on where it is billed: about $75.86 from a physician practice, and about $74.13 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$75.86$58.88 to $126
FacilityA hospital or hospital-owned outpatient department$74.13$74.13 to $126

How much rates vary

Facilitymedian $74 · 10th to 90th $62 to $126Professionalmedian $76 · 10th to 90th $30 to $158
$50$100$200facility $74professional $76

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$45.71
Median
$45.71
Typical High
$74.13
Aetna
Setting
Professional
Modifier
None
Typical Low
$43.65
Median
$43.65
Typical High
$61.66
Cigna
Setting
Facility
Modifier
None
Typical Low
$125.89
Median
$125.89
Typical High
$125.89
Cigna
Setting
Professional
Modifier
None
Typical Low
$75.86
Median
$125.89
Typical High
$158.49
Medica
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$74.13
Typical High
$74.13
Medica
Setting
Professional
Modifier
None
Typical Low
$30.20
Median
$58.88
Typical High
$120.23
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$93.33
Median
$151.36
Typical High
$177.83
United
Setting
Professional
Modifier
None
Typical Low
$27.54
Median
$38.90
Typical High
$66.07
Wellmark
Setting
Professional
Modifier
None
Typical Low
$66.07
Median
$66.07
Typical High
$66.07

Where South Dakota sits

The same service costs 3.4 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 14th of 51

$74.13

AK $148KY $43.65

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.