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MTHFR Gene Variant Test

Florida rates for HCPCS 81291

A blood test that checks for specific common changes in the MTHFR gene, which makes an enzyme the body uses to process folate, a B vitamin. Carrying these changes can alter how efficiently that step works. The test looks only for those known common changes rather than reading the whole gene.

Rates data updated July 2026.

Facilitymedian $110 · 10th–90th $47$2140%10%10th90th$110Professionalmedian $49 · 10th–90th $35$780%10%20%10th90th$49$5.0$10.0$20.0$50.0$100.0$200.0

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$46.77
Median
$100.00
Typical High
$213.80
Aetna
Setting
Professional
Modifier
Global
Typical Low
$36.31
Median
$48.98
Typical High
$77.62
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$39.81
Median
$39.81
Typical High
$39.81
AvMed
Setting
Facility
Modifier
Global
Typical Low
$57.54
Median
$66.07
Typical High
$77.62
AvMed
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$66.07
Typical High
$66.07
Cigna
Setting
Facility
Modifier
Global
Typical Low
$32.36
Median
$50.12
Typical High
$263.03
Cigna
Setting
Professional
Modifier
Global
Typical Low
$30.90
Median
$50.12
Typical High
$117.49
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$120.23
Median
$120.23
Typical High
$120.23
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$38.90
Typical High
$53.70
Molina
Setting
Professional
Modifier
Global
Typical Low
$29.51
Median
$32.36
Typical High
$74.13
United
Setting
Facility
Modifier
Global
Typical Low
$27.54
Median
$58.88
Typical High
$81.28
United
Setting
Professional
Modifier
Global
Typical Low
$22.91
Median
$27.54
Typical High
$100.00
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$26.92
Median
$66.07
Typical High
$66.07