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Alpha Thalassemia Gene Deletion Analysis

South Dakota rates for HCPCS 81257

This laboratory analysis looks at the genes responsible for making part of the hemoglobin protein in red blood cells, checking for missing or extra copies of genetic material that cause alpha thalassemia, an inherited blood condition. It's used to diagnose the condition, determine its severity, or check whether a person carries a copy that could be passed to children. The test is typically run on a blood sample.

Rates data updated July 2026.

How much does Alpha Thalassemia Gene Deletion Analysis cost?

$170

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $170 for this service. The price depends on where it is billed: about $135 from a physician practice, and about $195 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$135$79.43 to $240
FacilityA hospital or hospital-owned outpatient department$195$195 to $195

How much rates vary

Facilitymedian $195 · 10th to 90th $115 to $195Professionalmedian $135 · 10th to 90th $69 to $245
$50$100$200$500facility $195professional $135

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$70.79
Median
$117.49
Typical High
$117.49
Aetna
Setting
Professional
Modifier
Global
Typical Low
$69.18
Median
$79.43
Typical High
$95.50
Cigna
Setting
Facility
Modifier
Global
Typical Low
$194.98
Median
$194.98
Typical High
$194.98
Cigna
Setting
Professional
Modifier
Global
Typical Low
$147.91
Median
$194.98
Typical High
$245.47
Medica
Setting
Facility
Modifier
Global
Typical Low
$95.50
Median
$114.82
Typical High
$512.86
Medica
Setting
Professional
Modifier
Global
Typical Low
$52.48
Median
$52.48
Typical High
$512.86
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$147.91
Median
$239.88
Typical High
$281.84
United
Setting
Professional
Modifier
Global
Typical Low
$42.66
Median
$61.66
Typical High
$134.90
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$102.33
Median
$102.33
Typical High
$102.33

Where South Dakota sits

The same service costs 3.0 times more in Alaska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 2nd of 51

$170

AK $229DC $75.86

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.