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CYP2C9 Drug Metabolism Gene Test

South Dakota rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$200

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $200 for this service. The price depends on where it is billed: about $200 from a physician practice, and about $200 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$200$158 to $331
FacilityA hospital or hospital-owned outpatient department$200$200 to $331

How much rates vary

Facilitymedian $200 · 10th to 90th $166 to $331Professionalmedian $200 · 10th to 90th $89 to $417
$100$200$500facility $200professional $200

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$199.53
Aetna
Setting
Professional
Modifier
None
Typical Low
$117.49
Median
$117.49
Typical High
$165.96
Cigna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$331.13
Typical High
$331.13
Cigna
Setting
Professional
Modifier
None
Typical Low
$199.53
Median
$331.13
Typical High
$416.87
Medica
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$199.53
Typical High
$204.17
Medica
Setting
Professional
Modifier
None
Typical Low
$89.13
Median
$158.49
Typical High
$323.59
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$407.38
Typical High
$478.63
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$173.78
Wellmark
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78

Where South Dakota sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 10th of 51

$200

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.