go back

CYP2C9 Drug Metabolism Gene Test

Maryland rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$132

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $132 for this service. Most negotiated rates run $107 to $141.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $132 · 10th to 90th $79 to $174
$100$200professional $132

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$131.83
Typical High
$141.25
CareFirst
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$141.25
Typical High
$141.25
Cigna
Setting
Professional
Modifier
None
Typical Low
$81.28
Median
$123.03
Typical High
$501.19
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$208.93
Typical High
$263.03
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$87.10
Typical High
$151.36
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$138.04
Typical High
$138.04
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$64.57
Median
$66.07
Typical High
$70.79
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$25.70
Median
$26.30
Typical High
$28.18

Where Maryland sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 44th of 51

$132

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.