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CYP2C9 Drug Metabolism Gene Test

Indiana rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$148

Typical negotiated rate. In Indiana, July 2026.

Insurers have agreed to pay about $148 for this service. The price depends on where it is billed: about $145 from a physician practice, and about $174 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$145$93.33 to $145
FacilityA hospital or hospital-owned outpatient department$174$174 to $347

How much rates vary

Facilitymedian $174 · 10th to 90th $174 to $525Professionalmedian $145 · 10th to 90th $59 to $166
$100$200$500$1Kfacility $174professional $145

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$144.54
Median
$194.98
Typical High
$524.81
Aetna
Setting
Professional
Modifier
Global
Typical Low
$138.04
Median
$144.54
Typical High
$158.49
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$524.81
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$58.88
Median
$58.88
Typical High
$120.23
CareSource
Setting
Facility
Modifier
Global
Typical Low
$141.25
Median
$173.78
Typical High
$245.47
CareSource
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$199.53
Typical High
$245.47
Cigna
Setting
Facility
Modifier
Global
Typical Low
$125.89
Median
$173.78
Typical High
$331.13
Cigna
Setting
Professional
Modifier
Global
Typical Low
$79.43
Median
$162.18
Typical High
$257.04
United
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$199.53
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$208.93

Where Indiana sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 42nd of 51

$148

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.