go back

CYP2C9 Drug Metabolism Gene Test

Indiana rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$141

Typical negotiated rate. In Indiana, October 2026.

Insurers have agreed to pay about $141 for this service. The price depends on where it is billed: about $105 from a physician practice, and about $174 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$105$58.88 to $174
FacilityA hospital or hospital-owned outpatient department$174$158 to $380

How much rates vary

Facilitymedian $174 · 10th to 90th $138 to $525Professionalmedian $105 · 10th to 90th $59 to $263
$100$200$500$1K$2Kfacility $174professional $105

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$263.03
Typical High
$645.65
Aetna
Setting
Professional
Modifier
None
Typical Low
$131.83
Median
$144.54
Typical High
$263.03
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$138.04
Median
$173.78
Typical High
$524.81
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$263.03
CareSource
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$190.55
Typical High
$245.47
Cigna
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$173.78
Typical High
$489.78
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$158.49
Typical High
$338.84
Physicians Health Plan of Northern Indiana
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$436.52
Typical High
$2,187.76
Physicians Health Plan of Northern Indiana
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$147.91
Typical High
$269.15
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$208.93
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$66.07
Median
$72.44
Typical High
$131.83
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.30
Median
$28.84
Typical High
$52.48

Where Indiana sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 40th of 51

$141

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.