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CYP2C9 Drug Metabolism Gene Test

Connecticut rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$115

Typical negotiated rate. In Connecticut, October 2026.

Insurers have agreed to pay about $115 for this service. Most negotiated rates run $89.13 to $224.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $209 · 10th to 90th $76 to $437Professionalmedian $105 · 10th to 90th $76 to $263
$100$200$500facility $209professional $105

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$131.83
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$66.07
Median
$204.17
Typical High
$436.52
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$75.86
Median
$89.13
Typical High
$223.87
Cigna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$275.42
Typical High
$630.96
Cigna
Setting
Professional
Modifier
None
Typical Low
$97.72
Median
$223.87
Typical High
$389.05
ConnectiCare
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$229.09
Typical High
$281.84
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$223.87
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$57.54
Median
$57.54
Typical High
$61.66
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$22.91
Median
$22.91
Typical High
$24.55

Where Connecticut sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Connecticut· 50th of 51

$115

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.