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27-Gene Medication Response Test With Drug Interactions

South Dakota rates for HCPCS 0349U

Helps a clinician choose medications and doses that suit your genetics. Twenty-seven genes that affect how the body handles medicines are examined in either whole blood or a cheek (buccal) swab, and each gene is reported as a metabolizer type. This version also reports how specific medications interact with those gene results.

Rates data updated July 2026.

How much does 27-Gene Medication Response Test With Drug Interactions cost?

$1,259

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $1,259 for this service. Most negotiated rates run $692 to $1,778.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $851 · 10th to 90th $525 to $1,175Professionalmedian $1,413 · 10th to 90th $501 to $1,950
$500$1K$2Kfacility $851professional $1,413

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$524.81
Median
$851.14
Typical High
$851.14
Aetna
Setting
Professional
Modifier
Global
Typical Low
$501.19
Median
$575.44
Typical High
$691.83
Cigna
Setting
Professional
Modifier
Global
Typical Low
$1,071.52
Median
$1,412.54
Typical High
$1,778.28
Medica
Setting
Facility
Modifier
Global
Typical Low
$707.95
Median
$707.95
Typical High
$1,348.96
Medica
Setting
Professional
Modifier
Global
Typical Low
$380.19
Median
$380.19
Typical High
$3,715.35
Midlands
Setting
Professional
Modifier
Global
Typical Low
$891.25
Median
$891.25
Typical High
$891.25
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$1,071.52
Median
$1,737.80
Typical High
$2,041.74
United
Setting
Professional
Modifier
Global
Typical Low
$309.03
Median
$446.68
Typical High
$977.24
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$741.31
Median
$741.31
Typical High
$741.31

Where South Dakota sits

The same service costs 3.7 times more in Alaska than in Wyoming. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 3rd of 51

$1,259

AK $1,660WY $447

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.