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27-Gene Medication Response Test With Drug Interactions

California rates for HCPCS 0349U

Helps a clinician choose medications and doses that suit your genetics. Twenty-seven genes that affect how the body handles medicines are examined in either whole blood or a cheek (buccal) swab, and each gene is reported as a metabolizer type. This version also reports how specific medications interact with those gene results.

Rates data updated July 2026.

How much does 27-Gene Medication Response Test With Drug Interactions cost?

$741

Typical negotiated rate. In California, July 2026.

Insurers have agreed to pay about $741 for this service. The price depends on where it is billed: about $631 from a physician practice, and about $1,778 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$631$490 to $891
FacilityA hospital or hospital-owned outpatient department$1,778$977 to $3,467

How much rates vary

Facilitymedian $1,778 · 10th to 90th $631 to $4,677Professionalmedian $631 · 10th to 90th $309 to $1,479
$100$200$500$1K$2K$5K$10Kfacility $1,778professional $631

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$812.83
Median
$1,737.80
Typical High
$4,265.80
Aetna
Setting
Professional
Modifier
Global
Typical Low
$407.38
Median
$588.84
Typical High
$691.83
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$741.31
Median
$2,137.96
Typical High
$3,715.35
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$691.83
Median
$912.01
Typical High
$1,819.70
Blue Shield
Setting
Facility
Modifier
Global
Typical Low
$87.10
Median
$3,162.28
Typical High
$7,413.10
Blue Shield
Setting
Professional
Modifier
Global
Typical Low
$100.00
Median
$100.00
Typical High
$933.25
Cigna
Setting
Facility
Modifier
Global
Typical Low
$537.03
Median
$1,202.26
Typical High
$2,511.89
Contra Costa Health
Setting
Professional
Modifier
Global
Typical Low
$741.31
Median
$812.83
Typical High
$1,000.00
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$660.69
Median
$812.83
Typical High
$1,288.25
Lucent Health
Setting
Facility
Modifier
Global
Typical Low
$3,548.13
Median
$3,548.13
Typical High
$3,548.13
Lucent Health
Setting
Professional
Modifier
Global
Typical Low
$3,715.35
Median
$5,623.41
Typical High
$5,623.41
Providence
Setting
Facility
Modifier
Global
Typical Low
$501.19
Median
$891.25
Typical High
$1,698.24
Providence
Setting
Professional
Modifier
Global
Typical Low
$741.31
Median
$812.83
Typical High
$1,122.02
United
Setting
Facility
Modifier
Global
Typical Low
$741.31
Median
$851.14
Typical High
$1,122.02
United
Setting
Professional
Modifier
Global
Typical Low
$309.03
Median
$309.03
Typical High
$1,548.82

Where California sits

The same service costs 3.7 times more in Alaska than in Wyoming. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

California· 19th of 51

$741

AK $1,660WY $447

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.