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25-Gene Medication Response Test

Pennsylvania rates for HCPCS 0348U

Helps a clinician pick medications that suit your genetics and avoid ones your body may process poorly. Twenty-five genes that affect how the body handles medicines are examined in either whole blood or a cheek (buccal) swab, and each gene is reported as a metabolizer type. This version reports the gene results themselves, without an accompanying analysis of individual drug interactions.

Rates data updated October 2026.

How much does 25-Gene Medication Response Test cost?

$575

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $575 for this service. The price depends on where it is billed: about $575 from a physician practice, and about $891 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$575$525 to $631
FacilityA hospital or hospital-owned outpatient department$891$741 to $1,202

How much rates vary

Facilitymedian $891 · 10th to 90th $631 to $2,138Professionalmedian $575 · 10th to 90th $372 to $776
$500$1K$2Kfacility $891professional $575

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$630.96
Median
$1,047.13
Typical High
$2,511.89
Aetna
Setting
Professional
Modifier
None
Typical Low
$588.84
Median
$602.56
Typical High
$630.96
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$295.12
Median
$302.00
Typical High
$316.23
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$117.49
Median
$120.23
Typical High
$125.89
Capital Blue Cross
Setting
Professional
Modifier
None
Typical Low
$467.74
Median
$575.44
Typical High
$575.44
Cigna
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$1,023.29
Typical High
$1,698.24
Cigna
Setting
Professional
Modifier
None
Typical Low
$3,548.13
Median
$3,548.13
Typical High
$3,548.13
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$524.81
Median
$977.24
Typical High
$1,071.52
Geisinger
Setting
Facility
Modifier
None
Typical Low
$741.31
Median
$741.31
Typical High
$741.31
Geisinger
Setting
Professional
Modifier
None
Typical Low
$562.34
Median
$851.14
Typical High
$1,445.44
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$630.96
Median
$1,445.44
Typical High
$2,630.27
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$588.84
Median
$602.56
Typical High
$630.96
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$295.12
Median
$302.00
Typical High
$316.23
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$117.49
Median
$120.23
Typical High
$125.89
United
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$446.68
Typical High
$891.25

Where Pennsylvania sits

The same service costs 58.9 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 36th of 51

$575

TX $3,715AL $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.