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16-Gene Medication Response Test

North Carolina rates for HCPCS 0347U

Helps a clinician pick medications that suit your genetics and avoid ones your body may process poorly. Sixteen genes that affect how the body handles medicines are examined in either whole blood or a cheek (buccal) swab, and each gene is reported as a metabolizer type. It is the smallest gene set in this family of medication-response tests.

Rates data updated October 2026.

How much does 16-Gene Medication Response Test cost?

$1,349

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $1,349 for this service. The price depends on where it is billed: about $1,349 from a physician practice, and about $2,570 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$1,349$1,148 to $2,138
FacilityA hospital or hospital-owned outpatient department$2,570$1,072 to $6,026

How much rates vary

Facilitymedian $2,570 · 10th to 90th $1,072 to $6,026Professionalmedian $1,349 · 10th to 90th $871 to $3,467
$1K$2K$5Kfacility $2,570professional $1,349

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$1,071.52
Median
$1,071.52
Typical High
$1,071.52
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$1,047.13
Median
$1,071.52
Typical High
$1,174.90
BCBS North Carolina
Setting
Professional
Modifier
None (both parts)
Typical Low
$1,148.15
Median
$1,479.11
Typical High
$4,265.80
Cigna
Setting
Facility
Modifier
None
Typical Low
$1,949.84
Median
$3,548.13
Typical High
$6,025.60
Medcost
Setting
Facility
Modifier
None
Typical Low
$1,071.52
Median
$1,071.52
Typical High
$1,584.89
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$1,348.96
Median
$1,348.96
Typical High
$2,290.87
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$562.34
Median
$794.33
Typical High
$1,380.38
10 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$524.81
Median
$537.03
Typical High
$630.96
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$208.93
Median
$213.80
Typical High
$251.19
Medcost
Setting
Professional
Modifier
26 · Professional part
Typical Low
$537.03
Median
$537.03
Typical High
$1,000.00
Medcost
Setting
Professional
Modifier
50 · Both sides
Typical Low
$1,995.26
Median
$1,995.26
Typical High
$5,128.61
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$660.69
Median
$660.69
Typical High
$1,698.24
Medcost
Setting
Professional
Modifier
80 · Assistant surgeon
Typical Low
$269.15
Median
$269.15
Typical High
$691.83
Medcost
Setting
Professional
Modifier
81 · Minimal assistant surgeon
Typical Low
$186.21
Median
$186.21
Typical High
$478.63
Medcost
Setting
Professional
Modifier
82 · Assistant surgeon, no resident
Typical Low
$186.21
Median
$186.21
Typical High
$478.63
Medcost
Setting
Professional
Modifier
AS · PA/NP assist
Typical Low
$186.21
Median
$186.21
Typical High
$478.63
Medcost
Setting
Professional
Modifier
TC · Technical part
Typical Low
$1,230.27
Median
$1,230.27
Typical High
$2,290.87

Where North Carolina sits

The same service costs 104.7 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 15th of 51

$1,349

TX $6,607AL $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.