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Urine Two-Gene Prostate Cancer Risk Test

Massachusetts rates for HCPCS 0339U

Helps judge whether a man is likely to have prostate cancer serious enough to need a biopsy. The activity of two genes, HOXC6 and DLX1, is measured in a urine sample collected straight after a digital rectal examination, and the result is reported as a probability.

Rates data updated October 2026.

How much does Urine Two-Gene Prostate Cancer Risk Test cost?

$794

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $794 for this service. The price depends on where it is billed: about $759 from a physician practice, and about $1,995 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$759$457 to $1,995
FacilityA hospital or hospital-owned outpatient department$1,995$1,288 to $3,090

How much rates vary

Facilitymedian $1,995 · 10th to 90th $832 to $4,898Professionalmedian $759 · 10th to 90th $457 to $3,802
$100$200$500$1K$2K$5K$10Kfacility $1,995professional $759

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$1,071.52
Typical High
$2,398.83
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$537.03
Median
$537.03
Typical High
$537.03
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$831.76
Median
$1,949.84
Typical High
$2,630.27
AllWays Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$457.09
Median
$1,621.81
Typical High
$3,801.89
AllWays Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$3,801.89
Median
$3,801.89
Typical High
$3,801.89
Cigna
Setting
Facility
Modifier
None
Typical Low
$512.86
Median
$588.84
Typical High
$1,621.81
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$933.25
Median
$933.25
Typical High
$1,148.15
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$1,288.25
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$1,096.48
Median
$1,096.48
Typical High
$1,288.25
Harvard Pilgrim
Setting
Professional
Modifier
None (both parts)
Typical Low
$457.09
Median
$758.58
Typical High
$1,737.80
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$831.76
Median
$1,949.84
Typical High
$2,630.27
Mass General Brigham
Setting
Professional
Modifier
None (both parts)
Typical Low
$457.09
Median
$1,621.81
Typical High
$3,801.89
Mass General Brigham
Setting
Professional
Modifier
TC · Technical part
Typical Low
$3,801.89
Median
$3,801.89
Typical High
$3,801.89
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$302.00
Median
$457.09
Typical High
$1,445.44
Well Sense
Setting
Facility
Modifier
None
Typical Low
$2,511.89
Median
$3,467.37
Typical High
$5,128.61
Well Sense
Setting
Professional
Modifier
None (both parts)
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$263.03
Median
$263.03
Typical High
$263.03
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$107.15
Median
$107.15
Typical High
$107.15
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$758.58
Median
$977.24
Typical High
$1,174.90

Where Massachusetts sits

The same service costs 12.0 times more in Texas than in New Mexico. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 11th of 51

$794

TX $3,802NM $316

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.