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Urine Two-Gene Prostate Cancer Risk Test

California rates for HCPCS 0339U

Helps judge whether a man is likely to have prostate cancer serious enough to need a biopsy. The activity of two genes, HOXC6 and DLX1, is measured in a urine sample collected straight after a digital rectal examination, and the result is reported as a probability.

Rates data updated October 2026.

How much does Urine Two-Gene Prostate Cancer Risk Test cost?

$646

Typical negotiated rate. In California, October 2026.

Insurers have agreed to pay about $646 for this service. The price depends on where it is billed: about $631 from a physician practice, and about $1,995 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 10 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$631$339 to $3,236
FacilityA hospital or hospital-owned outpatient department$1,995$912 to $4,677

How much rates vary

Facilitymedian $1,995 · 10th to 90th $575 to $7,079Professionalmedian $631 · 10th to 90th $302 to $5,754
$50$200$1K$5Kfacility $1,995professional $631

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$575.44
Median
$1,318.26
Typical High
$4,365.16
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$575.44
Median
$645.65
Typical High
$645.65
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$1,905.46
Median
$3,801.89
Typical High
$3,890.45
Anthem BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$302.00
Median
$331.13
Typical High
$2,754.23
Blue Shield
Setting
Facility
Modifier
None
Typical Low
$1,000.00
Median
$4,365.16
Typical High
$8,317.64
Blue Shield
Setting
Professional
Modifier
None (both parts)
Typical Low
$346.74
Median
$489.78
Typical High
$1,318.26
Central California Alliance for Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$602.56
Median
$691.83
Typical High
$1,288.25
Cigna
Setting
Facility
Modifier
None
Typical Low
$549.54
Median
$1,000.00
Typical High
$2,041.74
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$1,819.70
Median
$1,819.70
Typical High
$1,949.84
Contra Costa Health
Setting
Professional
Modifier
None
Typical Low
$758.58
Median
$831.76
Typical High
$1,023.29
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$691.83
Median
$831.76
Typical High
$1,905.46
Lucent Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$3,801.89
Median
$5,754.40
Typical High
$5,754.40
Lucent Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$3,801.89
Median
$5,754.40
Typical High
$5,754.40
Providence
Setting
Facility
Modifier
None
Typical Low
$645.65
Median
$912.01
Typical High
$1,995.26
Providence
Setting
Professional
Modifier
None (both parts)
Typical Low
$758.58
Median
$831.76
Typical High
$1,318.26
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$316.23
Median
$457.09
Typical High
$3,388.44
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$281.84
Median
$660.69
Typical High
$2,187.76
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$114.82
Median
$263.03
Typical High
$870.96
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$281.84
Median
$323.59
Typical High
$323.59
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$114.82
Median
$128.82
Typical High
$128.82

Where California sits

The same service costs 12.0 times more in Texas than in New Mexico. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

California· 28th of 51

$646

TX $3,802NM $316

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.