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Tumor Tissue Gene Panel With MSI And TMB

Massachusetts rates for HCPCS 0334U

Guides treatment choice in solid tumors by identifying the genetic changes driving the cancer. Preserved, formalin-fixed tumor tissue is sequenced across at least eighty-four genes. The service also reports microsatellite instability and tumor mutational burden — two whole-tumor measures counted outside that gene total, which help predict response to immunotherapy.

Rates data updated July 2026.

How much does Tumor Tissue Gene Panel With MSI And TMB cost?

$3,467

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $3,467 for this service. The price depends on where it is billed: about $3,467 from a physician practice, and about $6,761 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,467$2,188 to $3,467
FacilityA hospital or hospital-owned outpatient department$6,761$4,074 to $10,000

How much rates vary

Facilitymedian $6,761 · 10th to 90th $2,042 to $10,715Professionalmedian $3,467 · 10th to 90th $1,738 to $6,026
$2K$5K$10Kfacility $6,761professional $3,467

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$2,041.74
Median
$6,606.93
Typical High
$11,220.18
Aetna
Setting
Professional
Modifier
Global
Typical Low
$1,584.89
Median
$2,041.74
Typical High
$2,344.23
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$3,890.45
Median
$7,762.47
Typical High
$16,595.87
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$3,467.37
Typical High
$10,000.00
Cigna
Setting
Facility
Modifier
Global
Typical Low
$2,290.87
Median
$2,290.87
Typical High
$6,165.95
Cigna
Setting
Professional
Modifier
Global
Typical Low
$3,548.13
Median
$4,265.80
Typical High
$5,128.61
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$83.18
Median
$5,888.44
Typical High
$9,772.37
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$5,011.87
Median
$5,011.87
Typical High
$5,888.44
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$3,467.37
Median
$3,467.37
Typical High
$5,888.44
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$3,890.45
Median
$7,762.47
Typical High
$16,595.87
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$3,467.37
Typical High
$10,000.00
United
Setting
Facility
Modifier
Global
Typical Low
$1,737.80
Median
$2,951.21
Typical High
$3,981.07
United
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$3,467.37
Typical High
$6,760.83

Where Massachusetts sits

The same service costs 6.5 times more in Alaska than in Montana. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 16th of 51

$3,467

AK $7,943MT $1,230

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.