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Targeted Gene Sequencing Analysis

Missouri rates for HCPCS 81405

This laboratory analysis examines the DNA sequence of a specific gene associated with an inherited condition, looking for changes that could explain a patient's symptoms or family history. It is one of many single-gene analyzes available, each ordered based on the particular condition being evaluated. Results help confirm a diagnosis or guide further testing and family counseling.

Rates data updated October 2026.

How much does Targeted Gene Sequencing Analysis cost?

$295

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $295 for this service. The price depends on where it is billed: about $275 from a physician practice, and about $525 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$275$200 to $479
FacilityA hospital or hospital-owned outpatient department$525$316 to $891

How much rates vary

Facilitymedian $525 · 10th to 90th $269 to $1,585Professionalmedian $275 · 10th to 90th $148 to $759
$100$200$500$1K$2Kfacility $525professional $275

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$389.05
Typical High
$549.54
Aetna
Setting
Professional
Modifier
None
Typical Low
$234.42
Median
$257.04
Typical High
$346.74
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$302.00
Typical High
$1,380.38
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$251.19
Median
$288.40
Typical High
$549.54
BCBS Kansas City
Setting
Facility
Modifier
None
Typical Low
$416.87
Median
$467.74
Typical High
$831.76
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$302.00
Typical High
$575.44
Cigna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$676.08
Typical High
$954.99
Cigna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$288.40
Typical High
$389.05
Medica
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$524.81
Typical High
$1,584.89
Medica
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$316.23
Typical High
$1,513.56
United
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$269.15
Typical High
$269.15
United
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$181.97
Typical High
$407.38
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$128.82
Median
$128.82
Typical High
$173.78
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$51.29
Median
$51.29
Typical High
$69.18

Where Missouri sits

The same service costs 3.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 28th of 51

$295

AK $676AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.