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Targeted Gene Sequencing Analysis

Maryland rates for HCPCS 81405

This laboratory analysis examines the DNA sequence of a specific gene associated with an inherited condition, looking for changes that could explain a patient's symptoms or family history. It is one of many single-gene analyzes available, each ordered based on the particular condition being evaluated. Results help confirm a diagnosis or guide further testing and family counseling.

Rates data updated October 2026.

How much does Targeted Gene Sequencing Analysis cost?

$224

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $224 for this service. Most negotiated rates run $191 to $240.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $224 · 10th to 90th $135 to $331
$200$500professional $224

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$223.87
Typical High
$257.04
CareFirst
Setting
Professional
Modifier
None
Typical Low
$218.78
Median
$239.88
Typical High
$263.03
Cigna
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$288.40
Typical High
$870.96
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$302.00
Median
$363.08
Typical High
$457.09
United
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$151.36
Typical High
$263.03
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$151.36
Typical High
$239.88
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$112.20
Median
$112.20
Typical High
$123.03
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$44.67
Median
$45.71
Typical High
$48.98

Where Maryland sits

The same service costs 3.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 44th of 51

$224

AK $676AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.