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Targeted Gene Sequencing Analysis

Illinois rates for HCPCS 81405

This laboratory analysis examines the DNA sequence of a specific gene associated with an inherited condition, looking for changes that could explain a patient's symptoms or family history. It is one of many single-gene analyzes available, each ordered based on the particular condition being evaluated. Results help confirm a diagnosis or guide further testing and family counseling.

Rates data updated October 2026.

How much does Targeted Gene Sequencing Analysis cost?

$234

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $234 for this service. The price depends on where it is billed: about $209 from a physician practice, and about $537 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$209$3.89 to $234
FacilityA hospital or hospital-owned outpatient department$537$363 to $1,047

How much rates vary

Facilitymedian $537 · 10th to 90th $302 to $1,905Professionalmedian $209 · 10th to 90th $3 to $363
$10$100$1Kfacility $537professional $209

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$426.58
Typical High
$912.01
Aetna
Setting
Professional
Modifier
None
Typical Low
$234.42
Median
$245.47
Typical High
$269.15
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$524.81
Typical High
$3,801.89
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$208.93
Typical High
$234.42
Cigna
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$630.96
Typical High
$1,258.93
Cigna
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$407.38
Typical High
$501.19
Hally Health
Setting
Professional
Modifier
None
Typical Low
$316.23
Median
$457.09
Typical High
$758.58
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$389.05
Median
$389.05
Typical High
$389.05
United
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$363.08
Typical High
$380.19
United
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$181.97
Typical High
$302.00
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$123.03
Median
$239.88
Typical High
$457.09
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$48.98
Median
$95.50
Typical High
$181.97
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$123.03
Typical High
$134.90
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$47.86
Median
$48.98
Typical High
$53.70

Where Illinois sits

The same service costs 3.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 43rd of 51

$234

AK $676AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.