go back

Targeted Gene Sequencing Analysis

Colorado rates for HCPCS 81405

This laboratory analysis examines the DNA sequence of a specific gene associated with an inherited condition, looking for changes that could explain a patient's symptoms or family history. It is one of many single-gene analyzes available, each ordered based on the particular condition being evaluated. Results help confirm a diagnosis or guide further testing and family counseling.

Rates data updated October 2026.

How much does Targeted Gene Sequencing Analysis cost?

$398

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $398 for this service. The price depends on where it is billed: about $182 from a physician practice, and about $871 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$182$126 to $389
FacilityA hospital or hospital-owned outpatient department$871$550 to $1,047

How much rates vary

Facilitymedian $871 · 10th to 90th $234 to $1,380Professionalmedian $182 · 10th to 90th $126 to $617
$200$500$1K$2Kfacility $871professional $182

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$524.81
Typical High
$1,380.38
Aetna
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$229.09
Typical High
$457.09
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$912.01
Typical High
$1,380.38
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$125.89
Typical High
$660.69
Cigna
Setting
Facility
Modifier
None
Typical Low
$177.83
Median
$363.08
Typical High
$954.99
Cigna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$223.87
Typical High
$436.52
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$269.15
Typical High
$380.19
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$426.58
Typical High
$630.96
Select Health
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$562.34
Typical High
$630.96
Select Health
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$302.00
Typical High
$457.09
United
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$363.08
Typical High
$363.08
United
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$125.89
Typical High
$223.87
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$104.71
Median
$114.82
Typical High
$158.49
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$42.66
Median
$45.71
Typical High
$64.57

Where Colorado sits

The same service costs 3.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 8th of 51

$398

AK $676AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.