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Definitive Urine Drug Test, 120 Or More Substances

Nationwide rates for HCPCS 0328U

Confirms exactly which medications and drugs are present in a person's urine and at what levels, whether for monitoring prescribed treatment or checking substance use. Mass spectrometry measures at least 120 individual substances, checks the sample for signs of tampering or dilution, and flags combinations that carry a risk of an adverse reaction. The service is charged once per date of service, however many substances turn up.

Rates data updated October 2026.

How much does Definitive Urine Drug Test, 120 Or More Substances cost?

$93.33

Typical negotiated rate. Nationwide, October 2026.

Insurers have agreed to pay about $93.33 for this service. The price depends on where it is billed: about $79.43 from a physician practice, and about $166 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 76 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$79.43$47.86 to $115
FacilityA hospital or hospital-owned outpatient department$166$115 to $309

How much rates vary

Facilitymedian $166 · 10th to 90th $85 to $550Professionalmedian $79 · 10th to 90th $32 to $170
$50$100$200$500$1K$2K$5Kfacility $166professional $79

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$85.11
Median
$128.82
Typical High
$524.81
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$43.65
Median
$61.66
Typical High
$263.03
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$17.38
Median
$24.55
Typical High
$107.15
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$93.33
Typical High
$138.04
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$35.48
Median
$46.77
Typical High
$69.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$14.13
Median
$18.62
Typical High
$27.54
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$85.11
Median
$102.33
Typical High
$169.82
AllWays Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$45.71
Median
$69.18
Typical High
$446.68
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$89.13
Median
$281.84
Typical High
$549.54
Anthem BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$28.84
Median
$45.71
Typical High
$162.18
Asuris Northwest Health
Setting
Facility
Modifier
None
Typical Low
$85.11
Median
$125.89
Typical High
$316.23
Asuris Northwest Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$85.11
Median
$102.33
Typical High
$114.82
AvMed
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$114.82
Typical High
$114.82
BCBS Alabama
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$162.18
Typical High
$162.18
BCBS Arizona
Setting
Facility
Modifier
None
Typical Low
$72.44
Median
$331.13
Typical High
$501.19
BCBS Arizona
Setting
Professional
Modifier
None (both parts)
Typical Low
$67.61
Median
$109.65
Typical High
$154.88
BCBS Arkansas
Setting
Professional
Modifier
None (both parts)
Typical Low
$102.33
Median
$102.33
Typical High
$154.88
BCBS Idaho
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$194.98
Typical High
$407.38
BCBS Idaho
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$100.00
Typical High
$117.49
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$138.04
Median
$154.88
Typical High
$186.21
BCBS Kansas
Setting
Professional
Modifier
None (both parts)
Typical Low
$144.54
Median
$144.54
Typical High
$144.54
BCBS Louisiana
Setting
Facility
Modifier
None
Typical Low
$125.89
Median
$229.09
Typical High
$363.08
BCBS Michigan
Setting
Facility
Modifier
None
Typical Low
$79.43
Median
$79.43
Typical High
$79.43
BCBS Michigan
Setting
Professional
Modifier
None (both parts)
Typical Low
$75.86
Median
$79.43
Typical High
$89.13
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$102.33
Median
$114.82
Typical High
$114.82
BCBS Minnesota
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$102.33
Typical High
$114.82
BCBS Mississippi
Setting
Facility
Modifier
None
Typical Low
$70.79
Median
$70.79
Typical High
$70.79
BCBS Mississippi
Setting
Professional
Modifier
None (both parts)
Typical Low
$70.79
Median
$70.79
Typical High
$70.79
BCBS Nebraska
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$131.83
Typical High
$263.03
BCBS North Carolina
Setting
Professional
Modifier
None (both parts)
Typical Low
$74.13
Median
$102.33
Typical High
$114.82
BCBS North Dakota
Setting
Professional
Modifier
None (both parts)
Typical Low
$147.91
Median
$194.98
Typical High
$229.09
BCBS Rhode Island
Setting
Facility
Modifier
None
Typical Low
$138.04
Median
$138.04
Typical High
$138.04
BCBS South Carolina
Setting
Professional
Modifier
None (both parts)
Typical Low
$114.82
Median
$114.82
Typical High
$123.03
BCBS Tennessee
Setting
Professional
Modifier
None (both parts)
Typical Low
$58.88
Median
$114.82
Typical High
$114.82
BCBS Texas
Setting
Professional
Modifier
None (both parts)
Typical Low
$114.82
Median
$114.82
Typical High
$114.82
Blue Shield
Setting
Facility
Modifier
None
Typical Low
$151.36
Median
$660.69
Typical High
$1,230.27
Blue Shield
Setting
Professional
Modifier
None (both parts)
Typical Low
$52.48
Median
$74.13
Typical High
$107.15
Capital Blue Cross
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$89.13
Typical High
$97.72
CareFirst
Setting
Professional
Modifier
None (both parts)
Typical Low
$83.18
Median
$91.20
Typical High
$91.20
CareSource
Setting
Facility
Modifier
None
Typical Low
$112.20
Median
$158.49
Typical High
$2,511.89
CareSource
Setting
Professional
Modifier
None (both parts)
Typical Low
$125.89
Median
$154.88
Typical High
$2,137.96
Central California Alliance for Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$91.20
Typical High
$147.91
Christus
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$114.82
Cigna
Setting
Facility
Modifier
None
Typical Low
$87.10
Median
$223.87
Typical High
$426.58
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$131.83
Median
$165.96
Typical High
$316.23
ConnectiCare
Setting
Professional
Modifier
None (both parts)
Typical Low
$53.70
Median
$67.61
Typical High
$128.82
Contra Costa Health
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$125.89
Typical High
$125.89
DeanCare
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$416.87
Typical High
$645.65
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$87.10
Median
$102.33
Typical High
$158.49
Emblem Health
Setting
Facility
Modifier
None
Typical Low
$77.62
Median
$125.89
Typical High
$257.04
Emblem Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$53.70
Median
$67.61
Typical High
$223.87
Excellus BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$109.65
Typical High
$125.89
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$194.98
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$165.96
Median
$165.96
Typical High
$194.98
Florida Blue
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$213.80
Typical High
$213.80
Florida Blue
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$69.18
Typical High
$102.33
Geisinger
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$114.82
Geisinger
Setting
Professional
Modifier
None (both parts)
Typical Low
$85.11
Median
$97.72
Typical High
$204.17
HMSA
Setting
Professional
Modifier
None (both parts)
Typical Low
$114.82
Median
$120.23
Typical High
$144.54
Hally Health
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$154.88
Typical High
$208.93
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$147.91
Median
$147.91
Typical High
$147.91
Harvard Pilgrim
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$114.82
Typical High
$331.13
Health Alliance Plan
Setting
Facility
Modifier
None
Typical Low
$109.65
Median
$109.65
Typical High
$316.23
Health Alliance Plan
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$54.95
Median
$54.95
Typical High
$85.11
Health Alliance Plan
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$21.88
Median
$21.88
Typical High
$33.88
Health Alliance Plan
Setting
Professional
Modifier
None (both parts)
Typical Low
$109.65
Median
$114.82
Typical High
$147.91
Health Alliance Plan
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$54.95
Median
$54.95
Typical High
$54.95
Health Alliance Plan
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$21.88
Median
$21.88
Typical High
$21.88
Health Partners
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$354.81
Typical High
$851.14
Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$131.83
Median
$131.83
Typical High
$218.78
Hometown Health
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$186.21
Horizon BCBS
Setting
Facility
Modifier
None
Typical Low
$912.01
Median
$18,197.01
Typical High
$27,542.29
Horizon BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$79.43
Median
$79.43
Typical High
$79.43
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$102.33
Median
$138.04
Typical High
$295.12
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$204.17
Typical High
$602.56
MVP Health Care
Setting
Professional
Modifier
None (both parts)
Typical Low
$74.13
Median
$74.13
Typical High
$234.42
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$218.78
Typical High
$407.38
Martin's Point
Setting
Professional
Modifier
None (both parts)
Typical Low
$93.33
Median
$93.33
Typical High
$97.72
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$46.77
Median
$46.77
Typical High
$48.98
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$18.62
Median
$18.62
Typical High
$19.50
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$85.11
Median
$102.33
Typical High
$169.82
Mass General Brigham
Setting
Professional
Modifier
None (both parts)
Typical Low
$45.71
Median
$69.18
Typical High
$446.68
Medcost
Setting
Facility
Modifier
None
Typical Low
$74.13
Median
$93.33
Typical High
$151.36
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$74.13
Median
$114.82
Typical High
$114.82
Medica
Setting
Facility
Modifier
None
Typical Low
$75.86
Median
$134.90
Typical High
$549.54
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$47.86
Median
$69.18
Typical High
$204.17
Medical Mutual of Ohio
Setting
Facility
Modifier
None
Typical Low
$74.13
Median
$134.90
Typical High
$630.96
Medical Mutual of Ohio
Setting
Professional
Modifier
None (both parts)
Typical Low
$74.13
Median
$74.13
Typical High
$74.13
Midlands
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$141.25
Typical High
$208.93
Moda Health
Setting
Facility
Modifier
None
Typical Low
$75.86
Median
$114.82
Typical High
$302.00
Moda Health
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$43.65
Median
$102.33
Typical High
$309.03
Moda Health
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$17.38
Median
$40.74
Typical High
$123.03
Moda Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$97.72
Typical High
$223.87
Moda Health
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$34.67
Median
$39.81
Typical High
$112.20
Moda Health
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$13.80
Median
$15.85
Typical High
$44.67
Molina
Setting
Professional
Modifier
None (both parts)
Typical Low
$63.10
Median
$81.28
Typical High
$144.54
MountainHealth Co-op
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$169.82
Typical High
$223.87
MountainHealth Co-op
Setting
Professional
Modifier
None (both parts)
Typical Low
$114.82
Median
$154.88
Typical High
$208.93
Network Health
Setting
Facility
Modifier
None
Typical Low
$123.03
Median
$138.04
Typical High
$331.13
Network Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$85.11
Median
$85.11
Typical High
$229.09
Pacific Source
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$128.82
Physicians Health Plan of Northern Indiana
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$288.40
Typical High
$363.08
Physicians Health Plan of Northern Indiana
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$97.72
Typical High
$100.00
Premera BCBS
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$199.53
Typical High
$398.11
Premera BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$102.33
Median
$102.33
Typical High
$257.04
Prevea360
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$93.33
Typical High
$138.04
Priority Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$131.83
Median
$131.83
Typical High
$138.04
Providence
Setting
Facility
Modifier
None
Typical Low
$77.62
Median
$123.03
Typical High
$309.03
Providence
Setting
Professional
Modifier
None (both parts)
Typical Low
$79.43
Median
$114.82
Typical High
$165.96
Quartz
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$263.03
Typical High
$346.74
Quartz
Setting
Professional
Modifier
None (both parts)
Typical Low
$295.12
Median
$295.12
Typical High
$295.12
Regence BlueShield
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$229.09
Typical High
$407.38
Regence BlueShield
Setting
Professional
Modifier
None (both parts)
Typical Low
$85.11
Median
$97.72
Typical High
$125.89
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$316.23
Security Health
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$245.47
Security Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$630.96
Median
$630.96
Typical High
$630.96
Select Health
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$239.88
Select Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$79.43
Median
$114.82
Typical High
$147.91
Sentara
Setting
Facility
Modifier
None
Typical Low
$81.28
Median
$131.83
Typical High
$257.04
Sentara
Setting
Professional
Modifier
None (both parts)
Typical Low
$81.28
Median
$131.83
Typical High
$257.04
SummaCare
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$97.72
Typical High
$138.04
U of Utah Health Plan
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$100.00
Typical High
$169.82
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$47.86
Median
$69.18
Typical High
$151.36
Univera
Setting
Facility
Modifier
None
Typical Low
$75.86
Median
$117.49
Typical High
$131.83
Univera
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$109.65
Typical High
$125.89
Well Sense
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$3,090.30
Typical High
$4,897.79
Well Sense
Setting
Professional
Modifier
None (both parts)
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
Wellmark
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$114.82
Typical High
$114.82
Wellpoint
Setting
Professional
Modifier
None (both parts)
Typical Low
$31.62
Median
$31.62
Typical High
$114.82
15 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$91.20
Median
$107.15
Typical High
$138.04
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$85.11
Median
$97.72
Typical High
$138.04
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$112.20
Median
$147.91
Typical High
$245.47
BCBS Alabama
Setting
Professional
Modifier
21 + 22 · Increased work + 24 · Unrelated visit after surgery + 31 + 55 · Aftercare only + 99 · Multiple modifiers
Typical Low
$72.44
Median
$74.13
Typical High
$83.18
BCBS Arkansas
Setting
Professional
Modifier
26 · Professional part
Typical Low
$7.24
Median
$7.24
Typical High
$10.72
BCBS Arkansas
Setting
Professional
Modifier
TC · Technical part
Typical Low
$95.50
Median
$95.50
Typical High
$144.54
BCBS North Dakota
Setting
Professional
Modifier
22 · Increased work
Typical Low
$177.83
Median
$234.42
Typical High
$275.42
Cigna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$26.30
Median
$123.03
Typical High
$177.83
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$112.20
Median
$549.54
Typical High
$549.54
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$114.82
Median
$147.91
Typical High
$177.83
Health Alliance Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$109.65
Median
$109.65
Typical High
$109.65
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$123.03
Median
$169.82
Typical High
$295.12
Medica
Setting
Facility
Modifier
TC · Technical part
Typical Low
$199.53
Median
$549.54
Typical High
$549.54
Midlands
Setting
Facility
Modifier
TC · Technical part
Typical Low
$138.04
Median
$138.04
Typical High
$158.49
Sentara
Setting
Professional
Modifier
TC · Technical part
Typical Low
$79.43
Median
$131.83
Typical High
$162.18

What it costs in each state

The same service costs 8.1 times more in Alaska than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Touch or drag across the chart to see any state's rate.

AK $257KY $31.62

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.